Anti-Dyslipidemia effectiveness of andaliman fruit extract (Zanthoxylum acanthopodium) in Wistar rats given a high fat diet and PTU (Propylthiouracil)

The andaliman fruit contains many phytochemicals, such as phenols, saponins, flavonoids, triterpenoids, and alkaloids, has various pharmacological effects as: anti-inflammatory, antioxidant, antidiabetic, antibacterial. This study aimed to explore the antidislipidemia effectiveness of extract. experimental used Pre-test Post-test group-only control design approach using Wistar male rats animals. sample size in this was calculated Federer formula; calculation showed that at least four (Rattus norvegicus) were needed each treatment group. First, research data analyzed descriptively (Central tendency Dispersion) lipid profile (LDL, HDL, Total cholesterol, Triglycerides), color, texture, weight. Then form profiles with One-Way Anova if normally distributed further tests Post Hoc Tukey HSD see fundamental differences between treatments. However, not distributed, Kruskall-Wallis test an alternative. results total cholesterol before being given a high-fat diet all groups did show significant (P value = 0.782). indicates rats' uniform diet. after diet, different distributions. Only control, standard, methanol extract-I, II, III had cholesterol. extract could significantly reduce triglyceride, LDL, SGOT levels compared In contrast, dramatically increase HDL